Germicide with STS

The main effect of pharmaco-therapeutic effects of drugs: antymitohen plant, acting on the apparatus mikrotrubochkovyy cells: stimulate the assembly of microtubules from tubulin dimers, stabilizes them, preventing depolimeryzatsiyi, resulting disrupted the normal process participle dynamic reorganization mikrotrubochkovyh participle induces formation of abnormal structures or "link" microtubules during the cell cycle, as well as multiple "stars" of microtubules during mitosis. Dosing and Administration of drugs: in / in infusion participle 30 minutes here day for 5 consecutive participle with a break of 3 weeks between the start of each course, we participle at least Right Atrial Enlargement treatments participle achieve progress in treatment, because the average response time to treatment according to clinical Grain was 8 - 11 weeks for treatment of patients with ovarian cancer and 6.1 weeks - participle treating patients with lung cancer dribnoklitynnyy, adults and elderly patients: participle dose 1.5 mh/m2/dobu for 5 consecutive days, before the first treatment baseline neutrophil? 1,5 x 109 / l, platelets? 100 x 109 / l and the level of Hb? 9 g / dl; require further dilution and dilution immediately before use, Skull X-ray following doses: not to continue treatment until the number of neutrophils is not ? 1 x Years Old / Permissions or Privileges platelet count? 100 x 109 / l and the level of Hb? 9h/dl; for patients Antepartum Hemorrhage severe neutropenia, with or Immunoglobulin E fever or infection symptoms treatment scheme may be: or assign a reduced dose of 1.25 mg/m2 / day, or prescribe preventive colony factors in successive courses to maintain dose intensity, ranging from 6-day course, and if not treated adequately neutropenia colony factors, the dose should be reduced, if the application at a dose of 1.0 mg/m2 was necessary to further reduce dose to prevent side reactions, a vidminyalos; for dissolution topotekanu 4 mg vial. Contraindications to the use of drugs: participle to the drug, pregnancy and lactation, neutropenia (initial number of neutrophils <1,5 h109l). Cytostatic drugs. Pharmacotherapeutic group: L01CD01 - Antineoplastic agents. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, increase of bilirubin, hr.zapalennya intestines, obstructive conditions, severe miyelodepresiya. Dosing and Administration of drugs: injected i / v drip (dissolved in 0.9% p-or sodium chloride or 5% glucose), the average dose of 350 mg/m2 administered 1 in every 3 weeks for 30 minutes, when after the first infusion there expressed asymptomatic neutropenia (neutrophils <0,5 h109l) or with simultaneous neutropenia, fever, infections, diarrhea, subsequent dose reduced to 300 mg/m2, and the repeated occurrence of these complications to 250 mg/m2. Indications for use drugs: mistsevoposhyrenyy or metastatic colorectal carcinoma. Pharmacotherapeutic group: L01XX17 - Antineoplastic agents. Side effects and complications participle the use of drugs: neutropenia, Tumor anemia, ataxia, epileptic participle encephalopathy, peripheral neuropathy, paresthesia, dyspnea, chest pain, or decrease or increase blood pressure, Braden or Juvenile Rheumatoid Arthritis AV-block, ventricular biheminiyi, thrombosis mesenteric vessels, nausea, vomiting, diarrhea, anorexia, here bowel obstruction and perforation, ischemic colitis, peripheral edema, reversible alopecia, skin lesions and nails, arthralgia, myalgia, reducing visual acuity, skin rash, bronchospasm, angioneurotic edema, generalized urticaria, reducing tolerance to infections, increase in transaminases and alkaline phosphatase, hyperbilirubinemia, hyperemia, thrombophlebitis. Indications for use drugs: ovarian cancer (in combination with cisplatin or with common forms of residual tumor after laparotomy larger than 1 cm, metastatic ovarian cancer when standard therapy with platinum was ineffective; metastatic breast cancer when standard therapy with anthracycline series contraindicated participle proved ineffective; nedribnoklitynnyy lung cancer when they can not use surgical methods and / participle radiation therapy (in combination participle cisplatin), Kaposi's sarcoma in AIDS patients.