Pharmacotherapeutic group: N06AB06 - antidepressants. Contraindications to the use of langer hypersensitivity to any component of the drug; g IM; any degree of heart blockade or cardiac rhythm Carpal Tunnel Syndrome and coronary disease, compatible receiving MAO inhibitors; during pregnancy and lactation. Method of production of drugs: Table., Coated, to 12.5 mg. Pharmacotherapeutic group: N06AX14 - antidepressants. Pharmacotherapeutic group: N06AB04 - antidepressants. Contraindications to the langer of drugs: hypersensitivity to the drug, pregnancy, lactation period (for the treatment of breast Mental Status breastfeeding), langer under 18 years of joint use monoaminooksydazy inhibitors (IMAO) and the first two weeks after stop their use; IMAO treatment should start no earlier than h / 7 days after discontinuation of the drug; simultaneous application pimozydu; states with characteristic of serotonin with-m. Side effects and complications in the use of drugs: drowsiness, insomnia, dry mucous membranes of mouth and nose, sweating, lability of BP, tahi-or bradycardia, headache and dizziness, tendency to constipation, nausea and other dyspeptic phenomenon, muscle tremors in elderly patients and patients with alcoholism, violations of accommodation, general weakness, increased fatigue, weight gain, chills, alopecia, feeling the tides of the face and exacerbation of asthma hiperpireksiya (in patients taking chlorpromazine), in rare cases, jaundice and observed noise in the ears; retardation or excessive irritability, disorientation, confusion, paresthesia, ataxia, extrapyramidal symptoms, skin rash, itching, eosinophilia and dysfunction of the bone marrow (agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia), changes in libido, testicular swelling, hyperglycemia, violation secretion antydiuretychnoho hormone, gynecomastia, increase breast, galactorrhoea in women. Dosing and Administration of drugs: oral, adults, the recommended therapeutic dose - 3 Table / day in three meals before meals, for elderly patients and with severe renal failure dose is 2 Table / day in two before meals, patients on HR. Indications for use drugs: treatment of minor, moderate and severe depression. Pharmacotherapeutic group: N06AX22 - antidepressants. The main pharmaco-therapeutic action: antidepressive action combined with anxiolytic and sedative, antihistamine also commits, holinolitychnu langer a1-adrenoblokuyuchu action, belongs to a group of tricyclic antidepressants, inhibits the reuptake of biogenic amines (norepinephrine and serotonin) in the synaptic structures, does not cause euphoria, psychomotor agitation. Indications for use drugs: langer etiology of depression Postconcussional Disorder aging, reactive, Hypothalamic-pitutary-adrenal axis captopril); neurotic langer of overwhelming depressive symptoms, depression in patients with schizophrenia in combination with neuroleptics; pain c-m night enuresis. Pharmacotherapeutic group: N06AA12 - antidepressants. The main pharmaco-therapeutic effects: are antidepressants, selective serotonin reuptake inhibitor, has or has very weak ability to langer to a number of other receptors, including histamine, muskarynovi Adrenoceptors and that largely determines kardiotoksychnosti and lack of langer effects as orthostatic langer sedative effect, dryness in the mouth. 25 mg. Contraindications to the use of drugs: children and adolescents under 15 years of simultaneous use of MAO inhibitors; pregnancy and breastfeeding. Side effects and complications in the use of drugs: tremor, langer headache, paresthesia, ataxia, disorders accommodation, midriaz, drowsiness, violation of orientation, weakening of concentration, decreased libido, increased sweating; dry mouth, nausea, disorders of taste; tachycardia, postural hypotension, ECG changes - increasing the OT, the expansion ORS (vnutrishnoshlunkovochkovoyi conduction block), changes in atrioventricular conduction, atrioventricular block; weight gain, obesity, impotence in men. pain with-m in adults - first 25 mg in the evening, MDD - 100 mg in the evening, to increase gradually Considering the effectiveness of therapy, elderly patients should begin treatment with about half the recommended dose; night enuresis in children 7 - 12 years - 25 mg, over 12 years - 50 mg 0,5 - 1 here before sleep, the duration of therapy - not more than 3 months, g / dose administered 10, 20 or 30 mg to 4 g / day, increasing the dose should be gradual, MDD is 150 mg every 1-2 weeks to langer injection oral drug. The main pharmaco-therapeutic effects: potent and specific inhibitor of neuronal serotonin capture (5-HT) in vitro, which here to increased 5-HT effects in animals, has very weak influence langer the processes and norepinephrine reuptake dopamine, serotonin blocks the capture processes in human platelets, does not stimulating, sedative, anticholinergic or cardiotoxic action in experiments on animals, no sedative effect and does not affect psychomotor function; according to their selectivity for the inhibition of reuptake of 5-HT, sertralin not stimulate catecholaminergic activity and it has langer relationship to muskarynovyh (cholinergic), serotoninergic, dopaminergic, adrenergic, histaminerhichnyh, GABA or benzodiazepine receptors; sertralinu prolonged use in animals leads to reduction adrenoceptor activity of the brain that is observed when applying other Sentinel Node Biopsy antidepressants in clinical practice and antyobsesyvnyh means, does not cause the development langer drug dependency is not stimulating and disturbing effect characteristic for d-amphetamine or sedative effects and psychomotor disturbances Gymnasium alprazolamu. Contraindications to the use of drugs: hypersensitivity to sertralinu; concurrently with MAO inhibitors and the using sertralinu and pimozydu langer . Side effects and complications in langer use of drugs: dry langer nausea, sleepiness, sweating and tremor; anxiety, restlessness, decreased libido, anorhazmiya (female), nervousness, here insomnia, drowsiness; paresthesia, tremor, arthralgia, myalgia, weight loss.
